it seemed to go to the end of the road. General Hospital of Chengdu Military Region decided to make an unprecedented attempt on Xiao Lin Hua, that is, the use of super CAR-T cell therapy. In January 15th,
2018 discovered the CAR-T cell in the small lotus flower body on the twenty-eighth day of the two degree relapse of leukemia. After 21 days of injection, Xiao Lin's condition has greatly improved. After assessing the bone marrow, the condition of Xiao Lin Hua was completely relieved.
Liu Fang, director of the hematopoietic stem cell transplantation center of General Hospital of Chengdu Military Region, said that super CAR-T cells can completely eliminate tumor cells by changing the microenvironment of tumor cells. The technology is developed by Yupo Ma, a professor at the New York State University Stony Brook campus, and is internationally patented by Liu Fang, the team leader. Xiao Lin Hua has become the world's first recipient of the super CAR clinical trial. The success of this attempt has brought more hope to the vast majority of leukemia patients.
Liu Fang told the Legal Evening News. The reporter detailed the treatment process of Xiao Lin Hua. "Because the tumor load of the peripheral blood is too high and the residual normal lymphocytes are very few, the culture of CAR-T cells is very difficult, so we adopt different ideas, that is to extract donor cells to cultivate CAR-T cells. In the process of waiting for CAR-T cell culture, we used the drug combination regimen that the children never used to reduce tumor chemotherapy, trying to reduce the tumor load, but the malignant cells were abnormally stubborn, and there was no lower head in front of chemotherapy, and the tumor load remained high. After the relapse of
small flowers, the symptoms of GVHD (graft-versus-host disease) gradually appeared, and continued non infectious hyperthermia, elevated cytokines and diarrhea. Although the cells have been prepared, they may aggravate the symptoms and endanger life. On the other hand, the tumor burden of the girl is very high. After transfusion of CAR-T cells, the lethal cytokine storm and organ failure may occur rapidly. If the tumor cells are not allowed to grow freely, the patients will soon be swallowed up by tumor cells and die.
little Lin flower: I hope to see Jiuzhaigou
"when the body is fully rehabilitate," all of them are facing death. Threats, we are in a dilemma. " Liu Fang said.
"in January 15, 2018, on the twenty-eighth day of the relapse, our first CAR-T cell slowly entered the little girl. Second days after the infusion, the girl's temperature was high and the cytokine rose sharply. We immediately thought of respiratory failure soon, even communicating with the family in advance, ready to go to ICU at any time. It is strange that, for 3 days, the little girl's body temperature is miraculously normal, and she has been depressed before her spirit, and her appetite has opened, and all the discomfort has disappeared. Liu Fang said excitedly.
followed by the repeated infusion of two doses of CAR-T cells on the basis of the first infusion. After each infusion, an excessive fever reaction and a slight increase in cytokines were occurring after each infusion, but each time lasted only a short period of time and was restored to normal without any treatment.
it is more surprising that the diarrhea symptoms of Xiao Lin flower gradually disappear, the stool is completely restored to normal, and the diarrhea and other GVHD symptoms are not reappeared after infusion of CAR-T cells.
"we evaluated her bone marrow for the first time, and the detection of bone marrow minimal residual leukemia was negative. In conclusion, our first super CAR clinical trial results show that the CAR-T cell is safe and effective against refractory B-ALL. Liu Fang said.
but Liu Fang also pointed out that although this cell therapy technique is quite mature and complete remission rate can be as high as 80%, there is still some inevitable recurrence for patients with effective CAR-T cells.
at present, Xiao Lin flower is still recovering. She hopes to see Jiuzhaigou and walk around after her complete recovery.