Drug use survey for children in Ji'nan: dosage without standard medication
7 12 months, a 3 year old girl died from a 3 year old girl who died of "overdose" in a group of adverse drug reactions in the prevention of medication in Sichuan. The problem of the safety of drugs for children has been reigned again. Reporters visited Ji'nan hospital in July 23rd and found that overdose in children is more common in clinical practice. The lack of medication in children indicates that the drug instructions for children's usage and dosage are "children's discretionary reduction" or "doctor's advice".
5 years old boy took medicine overdose
a day before, Anan, 5 years old, went down to a hospital in Ji'nan, and the doctor opened the "stomach Fu an" for him. The instructions indicate that "metoclopramide" is 5 mg per tablet, 1 to 2 tablets for adults 1 times, 3 times for 1 days, children taking 1 to 2.5 mg each time, 3 times. That is to say, parents need to break the tablets by themselves, so that ANN can take them. After
taking a few days, Ann's symptoms improved, but there was excitement and general spasticity. The doctor asked to know that Ann's parents watched the children vomit and looked forward to their children's illness. Finally, the adverse reactions of ANN were improved obviously after doctors treatment.
because of the lack of special drugs for children, the use of adult tablets has long been a common practice for hospitals and parents to give their children medication. At the same time, the "children's discretion", "compliance with the doctor's advice", and even the complex "math problems" based on the amount of children's weight calculation have also laid a hidden danger for children's safety.
conversion, the amount of children over adult?
"how to give the child is a headache", "the usage and dosage of the instructions do not understand", "sometimes only by feeling"... Today, when interviewed by a number of hospitals in the city, many parents have similar feelings. "Before, when the child caught a cold, I took the medicine according to the dosage of the instructions. But last time I accidentally calculated it, I found that the child took more drugs than adults in one day. During the interview, Ms. Zhang told reporters about her own experience. Ms. Zhang said, the drug instructions are marked on adults, 0.5 grams a day, three times a day... One day dose is not more than 4 grams; children's daily dose is 20 to 40 mg / kg according to body weight. Her son is 13 years old and weighs 50 kilograms. If it is calculated by 40 mg / kg, the dose should be 2 grams a day, while the adult's one day dose is 1.5 grams, and the child is more than the adult in one day. "The labels on the instructions appear to be problematic, but now we are afraid of it. Fortunately, there is nothing wrong with it." Ms. Zhang said. "Overdose in children is more common in clinical practice. If children use more medicines, such problems will be solved." Li Peijie, the director of the Department of Pediatrics of the municipal maternity and child health care hospital, said. In his opinion, there are more than half of children's medication gaps. "Children's medication shows little variety and less specifications. Children under the age of 14 should calculate the amount of their weight according to their weight. The amount of drug used in children of every age is different. If there is a special medication for children of every age, it is the ideal state. " The data show that the proportion of children's drug formulations is less than 2% among the more than 3500 pharmaceutical preparations in China. According to a statistics from the State Administration of drug control, 90% of our medicines do not have children's dosage forms. Li Peijie said that when new drugs were used in clinical trials of children, most of them were converted by animal experiments or adult clinical trials, which is not scientific. "Children are not proportionate adults." Guo Ruichen, director of the Institute of clinical pharmacology of Qilu Hospital, bluntly pointed out that it was not scientific to calculate children's weight according to weight and other factors, and neglected the metabolic ability of children. If you want to control dosage strictly and scientifically, one way is to measure the blood concentration, but this is rather troublesome. Therefore, it is also a failure to convert the amount according to body weight.
"Chinese version" of the "Chinese version" standard for children to use drug
since children are more than the supply of drugs, why does the pharmaceutical factory do not strive to occupy this "commanding point"? The reporter learned from a well-known pharmaceutical company from outside the province, of the more than 20 medicines produced in the pharmaceutical factory, only two kinds of drugs are used for children. The reason is simple: "the production process of children is the same, but the price is lower than that of adults, and the profit is less".
it is understood that in June this year, the World Health Organization issued the first medication manual for all countries, called the "standard set of children of the WHO", which provides information on the use of more than 240 basic drugs for the treatment of children from 0 to 12 years old, which means that practitioners around the world can gain access to children and children. Standard information on drug usage, dosage, side effects and contraindications. "On this basis, the" Chinese version "standard of child medication is also urgently needed. During the interview, many pediatricians told reporters this.
provincial Qianfo Hill Hospital Department of Pediatrics Department of Pediatrics Yao Hui reminded, in the use of children to avoid two misunderstandings: try not to buy medicine for their own children, to the hospital to make a doctor for the children to diagnose the child, and to explain the dosage of drugs; do not make the children's disease fast and good, to increase the dosage without authorization.